Medical Literature
Efficacy of
Computerized Infrared Imaging Analysis to Evaluate Mammographically Suspicious
Lesions Y. R. Parisky1, A. Sardi2, R. Hamm3,
K. Hughes4, L. Esserman5, S. Rust6 and K.
Callahan7 Am. J. Roentgenol., August 1, 2003; 181(2): 596 -
596.
OBJECTIVE. The purpose of this clinical trial was to determine
the efficacy of a dynamic computerized infrared imaging system
for distinguishing between benign and malignant lesions in patients
undergoing biopsy on the basis of mammographic findings.
SUBJECTS AND METHODS. A 4-year clinical trial was conducted
at five institutions using infrared imaging of patients for whom
breast biopsy had been recommended. The data from a blinded subject
set were obtained in 769 subjects with 875 biopsied lesions resulting
in 187 malignant and 688 benign findings. The infrared technique
records a series of sequential images that provides an assessment of
the infrared information in a mammographically identified area. The
suspicious area is localized on the infrared image by the radiologist
using mammograms, and an index of suspicion is determined, yielding a
negative or positive result.
RESULTS. In the 875 biopsied lesions, the index of suspicion resulted
in a 97% sensitivity, a 14% specificity, a 95% negative predictive value,
and a 24% positive predictive value. Lesions that were assessed
as false-negative by infrared analysis were microcalcifications, so
an additional analysis was performed in a subset excluding lesions
described only as microcalcification. In this restricted subset of
448 subjects with 479 lesions and 110 malignancies, the index of
suspicion resulted in a 99% sensitivity, an 18% specificity, a 99%
negative predictive value, and a 27% positive predictive value.
Analysis of infrared imaging performance in all 875 biopsied lesions
revealed that specificity was statistically improved in dense breast
tissue compared with fatty breast tissue.
CONCLUSION. Infrared imaging offers a safe noninvasive procedure that would be
valuable as an adjunct to mammography in determining whether a lesion
is benign or malignant.
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